PAX6 methylation and ectopic expression in human tumor cells
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چکیده
منابع مشابه
Promoter Methylation and Gene Expression in Human CD34+ Stem Cells Derived Erythroid Lineage by MicroRNA
Background: Stem Cell differentiation is a process composed of vast variety of factors which are controlled by a network of certain mechanisms. This study aims to determine the possible role of DNA methylation, a potent regulator of VHL, ECAD and RUNX3 genes during Erythroid differentiation driven by miR-451. Materials and Methods: To determine the methylation status of promoters and the e...
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The process of metastasis is complex consisting of a series of sequential steps. Initially, tumor cells detach from the primary tumor, migrate through the surrounding tissue and eventually invade the lymphatic system or blood vessels. As a next step, circulating tumor cells temporarily adhere to endothelial cells and then extravasate by infiltrating the underlying basement membrane. Finally, ce...
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AIMS To investigate the changes in PAX6 expression in the developing human eye. METHODS Six developing human eyes from 6 to 22 weeks' gestation were evaluated. Frozen sections were immunohistochemically stained with monoclonal antibody to chick Pax6 (amino acids 1-223). To verify antibody specificity, western blot analysis was carried out using cell lysates from P19 cells transfected with the...
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We report here that misexpression of the transcription factor Pax6 in the vertebrate Xenopus laevis leads to the formation of differentiated ectopic eyes. Multiple molecular markers indicated the presence of mature lens fiber cells, ganglion cells, Müller cells, photoreceptors and retinal pigment epithelial cells in a spatial arrangement similar to that of endogenous eyes. Lineage tracing exper...
متن کاملpromoter methylation and gene expression in human cd34+ stem cells derived erythroid lineage by microrna
background: stem cell differentiation is a process composed of vast variety of factors which are controlled by a network of certain mechanisms. this study aims to determine the possible role of dna methylation, a potent regulator of vhl, ecad and runx3 genes during erythroid differentiation driven by mir-451. materials and methods: to determine the methylation status of promoters and the expres...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2000
ISSN: 0020-7136,1097-0215
DOI: 10.1002/1097-0215(20000715)87:2<179::aid-ijc4>3.0.co;2-x